The InterX is applied to the skin, typically at the site of pain/inflammation. It is often applied along the spinal column to stimulate the nerve roots of the spinal nerves. The patient feels a comfortable prickling sensation. In cases of very pronounced pain the device sends a stronger pulse to counterbalances the pain.

The area of the treatment has to be uncovered as the InterX requires contact with the skin. On some occasions where hair prevents full contact a comb attachment can be used.